The Science Behind Collagen for Joint Health: Undenatured vs. Hydrolysed Collagen

Joint health is essential for maintaining mobility, flexibility, and overall quality of life. With ageing, physical activity, and certain health conditions, our joints can become stiff and painful due to cartilage degradation. Collagen, the most abundant protein in the body, plays a crucial role in maintaining joint integrity.

You may have heard of these two commonly referred to forms of collagen - undenatured collagen and hydrolysed collagen - which have been extensively studied for their benefits in supporting joint health. Let’s explore how they work and their key advantages.

 

Scientific Insights into Collagen and Joint Health

A recent peer-reviewed study published in 2023 by Martínez-Puig D and others in PubMed, "Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge" (PubMed), highlights the distinct mechanisms of undenatured and hydrolysed collagen in promoting joint health.

The study emphasises that:

Different Mechanisms of Action: Native (undenatured) collagen primarily modulates the immune response to reduce inflammation, while hydrolysed collagen provides peptides that may reach joint tissues and exert chondroprotective effects.

Preclinical and Clinical Evidence: Both forms of collagen have been studied for their safety and efficacy, demonstrating a clear link between their chemical structure and their respective mechanisms of action.

These insights reinforce the unique benefits of undenatured and hydrolysed collagen in supporting joint health, as detailed below.

 

Undenatured Collagen: Supporting Joint Immunity and Cartilage Preservation

Undenatured type II collagen is derived from cartilage (commonly derived from chicken or bovine cartilage) and retains its natural triple-helix structure. Unlike hydrolysed collagen, which is broken down into smaller peptides, undenatured type II collagen works through an immune-mediated mechanism known as 'oral tolerance'.

Here’s how it benefits joint health:

Modulating the Immune Response: Undenatured type II helps prevent the immune system from attacking joint cartilage by promoting oral tolerance. This reduces inflammatory responses that contribute to cartilage breakdown.

Cartilage Protection: By reducing inflammation, undenatured type II helps slow down cartilage degradation, preserving joint structure and function over time.

Proven Joint Comfort Support: Clinical studies have shown that undenatured type II supplementation can improve joint flexibility and reduce discomfort, often outperforming glucosamine and chondroitin.

A common form of undenatured type II collagen is bone broth, however, there are also freeze-dried cartilage powder forms on the market, often available in capsule form.

 

Hydrolysed Collagen: Building Blocks for Joint Repair

Hydrolysed collagen, also known as collagen peptides, is broken down into smaller amino acids that are easily absorbed and used by the body. It provides essential peptides and amino acids beneficial for joint health:

Stimulating Collagen Synthesis: Hydrolysed collagen delivers key amino acids like glycine, proline and hydroxyproline, which stimulate the body’s natural collagen production.

Supporting Cartilage Regeneration: Collagen peptides enhance cartilage matrix production, improving its resilience and reducing joint wear and tear.

Reducing Joint Pain and Stiffness: Regular supplementation with hydrolysed collagen has been linked to reduced joint discomfort, particularly in athletes and individuals with osteoarthritis.

 

Which Collagen is Right for You?

Both undenatured and hydrolysed collagen offer unique benefits for joint health. If you’re looking for immune support and inflammation reduction, undenatured type II collagen is a good option. If you are looking for joint structural support for cartilage regeneration and overall joint strength, hydrolysed collagen can provide the necessary building blocks by providing bioavailable amino acids.

There is a good argument to use both undenatured collagen sources and hydrolysed collagen as part of a balanced, healthy diet to support overall joint health. By incorporating a source of undenatured type II like bone broth, the inflammatory autoimmune response may be reduced, and by incorporating a high-quality hydrolysed collagen, this can protect and support joint connective tissue repair. Thus, complimentary use can be beneficial as part of a holistic approach.

As always, when it comes to specific health conditions, it is best to consult with a doctor or medical professional, as they are able to provide an individualised approach to a person's specific health needs.

 

Reference:

Martínez-Puig D, Costa-Larrión E, Rubio-Rodríguez N, Gálvez-Martín P. Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge. Nutrients. 2023 Mar 8;15(6):1332. doi: 10.3390/nu15061332. PMID: 36986062; PMCID: PMC10058045.

Disclaimer: As with any dietary choice, it's essential to strike a balance. A varied and balanced diet, coupled with a healthy lifestyle, is key to overall well-being. This content is for informational purposes only and does not constitute medical advice. Consult with your Doctor or healthcare professional regarding your individual health needs before making any changes to your health routine or starting any new dietary supplements.